Lack of an association between clinical INSTI-related body weight gain and direct interference with MC4 receptor (MC4R), a key central regulator of body weight.
An increasing prevalence of overweight and obesity in people living with HIV has been associated with initiation of antiretroviral therapy with integrase strand transfer inhibitors (INSTIs).An off-target inhibition of the endogenous ligand binding to the human melanocortin 4 receptor (MC4R) has PUMPS CLIT/PUSSY been suggested as a potential mechani